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It shows anti-inflammatory properties as well as broad-spectrum anti-parasitic activity, each of which may contribute to its efficacy in treating rosacea. The efficacy percentages introduced listed here are these upon which the regulatory approvals have been based. In earlier research in our laboratory, we had established 100 µg/g as the ivermectin focus for in vitro testing, which was adapted from the in vitro acaricidal experiments of Brimer et al. The determination of sensitivity to ivermectin of mite populations was assessed at a concentration of one hundred µg/g of ivermectin (Equimec Paste; Merial Australia) diluted in Emulsifying Ointment British Pharmacopoeia 88 (BP88) (Sigma Pharmaceuticals).


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